Autoimmune condition in which dietary proteins (glutens), activate an abnormal mucosal response with chronic inflammation and damage (villous atrophy) to the lining of the small intestine. AKA gluten-sensitive enteropathy, coeliac sprue, non-tropical sprue.≠ 'gluten intolerance'.

Can present with a wide range of clinical features, both GI (indigestion, diarrhoea, abdominal pain, bloating, and constipation) and non-GI (such as fatigue, anaemia, dermatitis herpetiformis, osteoporosis, fertility problems, short stature, delayed puberty, and peripheral neuropathy)

Exclude – initially with an antibody screen. IgA transglutimase antibody is the test of choice with specificity and sensitivity at least as good as endomysial antibody.

Coeliac disease (NHS Choices), Coeliac disease (CKS), Coeliac disease: recognition, assessment and management (NICE, 2015), Coeliac disease (Medicines complete, 2016), Coeliac UK (coeliac.org.uk)